Thesaurus

DIA Site Localization

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https://bitbucket.org/searleb/thesaurus

Description

The human phosphorylation regulatory network represents a complex signaling cascade where proteins can be phosphorylated at multiple sites resulting in different functional states. Here we present Thesaurus, a hybrid search engine that detects, localizes, and quantifies novel positional isomers using site-specific fragment ions directly from data independent acquisition mass spectrometry experiments. This software works for several PTMs in addition to phosphorylation.

The Thesaurus project has been merged into EncyclopeDIA, a joint open source project with the same goals. You can now access the latest version of Thesaurus in encyclopedia-0.9.5 or higher.

Citation

Searle BC, Lawrence RT, MacCoss MJ, Villén J. Thesaurus: Quantifying phosphopeptide positional isomers. Nat Methods. 2019 Aug;16(8):703-706. Publication